2) The Bases of the Modern Gene Concept

The physiological units
The cytological discontinuities
The separate units of the chromosomes

3) Position Effects and the Effects of Rearrangements

Types of position effects: pure and mimic
Heterochromatin in position effects
The causality of the position effects
Proposed explanations of the position effect

Kinetic hypotheses
Structural hypotheses

4) Heterochromatization, Mimic and Pure Position Effects and Gene Action

Variegation and the nature of heterochromatin
Heterochromatization and euchromatization
Euchromatic-euchromatic rearrangements
Pure position effects, repeats and deficiencies

5) Principles of Gene and Rearrangement Physiology

Isomorphic and antimorphic gene action
Enzymes and genes
The quanta of mutation

6) Gene and Chromonema Evolution

Intra- and inter-group genetic differences
Genetic control of mutation rate and amplitude
Genetic nature of small amplitude mutations
The origin of new genetic materials
Genic inactivation: origin of heterochromatin

7) Composition of Chromonemata and Genes and the Nature of Gene Mutations

Production of chromonema breaks
Radiation induced breaks
Chemical production of breaks
Spontaneous breaks
Production of gene mutations
The composition of chromonemata and chromosomes

Are the genes nucleoproteins?
Proteins of the chromosomes
Physical state of the chromonema proteins
Composition of the gene

The genes as a physico-chemical unit
Architectural theories
The cyto-physiological theory of the gene

The physiological approach
The cytochemical approach
Conclusions on the structure of the chromonema and the gene
The process of gene diversification and the nature of gene mutations

Metabolism of chromosome compounds
Mutation and faulty redupication
Gene mutation as a structural change
The problem of directed mutation

8) Summary

Literature Cited